Scientist (T-Cell Engineering)

Our client, a biopharmaceutical company based near Cambridge, is looking for a Scientist (T-Cell Engineering) to join their growing research team. Candidates should be comfortable with a fast-paced, dynamic working environment and hold good communication skills to facilitate the necessary close interactions with the internal teams as well as external partners. KEY RESPONSIBILITIES: * Planning and execution of a wide range of robust experiments, technical studies, and tasks, working independently based on protocols and in line with departmental objectives. * Assaying of our client’s engineered delivery vehicle using flow cytometry, western blot, ELISA, and immunofluorescence. * Inform and implement the design of novel genetic constructs for use in T Cell engineering. * Development of robust T Cell engineering platform. * Development of T Cell functionality assays. * Cell culture (propagation, banking, characterisation) of cell lines and primary cells. * Timely, accurate recording and analysis of results and compliance with data integrity procedures. * Timely presentation of data to the department and wider company. * Contribution to critical interpretation of data to draw results driven hypotheses, with influence on project/function direction. It is essential that candidates have the following skills and experience: * A PhD with experience in T Cell biology (or equivalent experience gained in industry). Engineering of T Cells for the purpose of CAR-T generation with Lentiviral or CRISPR based systems is a plus. * Experience handling and culturing a range of cell lines. * Experience with CRISPR based editing of primary human T Cells, both KO and KI * Experience with genetic approaches for quantifying T Cell engineering outcomes. * Experience with assays of T Cell functionality and potency, especially in the context of CAR-T. * Strong experience with flow cytometry-based assays. * Experience with single cell sequencing assay. * Fluency in spoken and written English. * Proficiency with critical interpretation of data and implementation into an experimental cascade. * Communication in a clear, well-structured, and professional manner with key stakeholders within the company on a regular basis. * Contribution to authoring of technical and science reports which will feed into IND filings. * Awareness of latest scientific literature in company-relevant projects and general scientific areas